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Microbial genes for secreted β-glucuronidases, gene products and uses thereof (GUSPlus™)

Modified glucuronidase genes from Escherichia coli and glucuronidase genes from other microbes which encode forms of β-glucuronidase with different properties, e.g. those described in US patents 6,391,547, 6,641,996, 7,087,420 and 7,141,719.  Issued in Europe as European Patent 1012294, in Australia as Patent Number 760275, and in New Zealand as Patent Number 1485.   Published as WO 00/055333 and WO 99/13085 and pending in Brazil, Canada, Europe and Israel.

Secreted forms and thermophilic forms are provided. These genes and the proteins they encode may be used as effectors in transformation of plant cells, and for other uses in plant biotechnology, animal, human health and industrial applications.

These genes and use of the proteins they encode are available under a BiOS license, which allows both research and commercial application.

More information about GUSPlus and other glucuronidase genes

IP Portfolio licensable from Cambia

Cambia is in the process of implementing its new policy to maximize the public use of its work product.   To this end, we intend to a) abandon all of our patent protection over our inventions and no longer require licensing of any type, and b)  and to longer restrict use of our physical materials through materials transfer agreements (MTA).


We will simply ask that all users of technology or know-how from Cambia acknowledge our contribution to your work.  Those who wish to contribute financially are of course welcomed to do so.


This new policy will be announced publicly in due course.

Biological Gene Transfer System for Eukaryotic Cells (TransBacter™)

Microbial genes for secreted β-glucuronidases, gene products and uses thereof (GUSPlus™)

β-Glucuronidase (GUS) and Glucuronide Permease Gene System

Chimeric Genes - Gene Fusion Comprising Glucuronidase (gus)

A Gene Coding for Glucuronide Permease

Glucuronide Repressors and Uses Thereof

Preparation of Cellobiuronic Acid from Polysaccharide

Vertebrate Telomerase and Splice Variants

Methods for Site-Associated Modification of Gene Activity and Nucleic Acid (Trans-activation or TARGET)

Megagametophyte-specific Transcriptional Control Elements and Uses Thereof

Fungal β-glucuronidase Genes and Gene Products

Methods for Genotyping by Hybridization Analysis (Diversity Arrays Technology, DArT™)