IP Portfolio licensable from CAMBIA
Biological Gene Transfer System for Eukaryotic Cells (TransBacter™)
Microbial genes for secreted β-glucuronidases, gene products and uses thereof (GUSPlus™)
β-Glucuronidase (GUS) and Glucuronide Permease Gene System
Chimeric Genes - Gene Fusion Comprising Glucuronidase (gus)
A Gene Coding for Glucuronide Permease
Glucuronide Repressors and Uses Thereof
Preparation of Cellobiuronic Acid from Polysaccharide
Vertebrate Telomerase and Splice Variants
Methods for Site-Associated Modification of Gene Activity and Nucleic Acid (Trans-activation or TARGET™)
Megagametophyte-specific Transcriptional Control Elements and Uses Thereof
Fungal β-glucuronidase Genes and Gene Products
Methods for Genotyping by Hybridization Analysis (Diversity Arrays Technology, DArT™)
β-Glucuronidase (GUS) and Glucuronide Permease Gene System
The invention relates to the β-glucuronidase (GUS) gene fusion system, and to the cloning and characterisation of the β-glucuronidase and glucuronide permease genes of Escherichia coli. Because of the abundance and availability of useful substrates for β-glucuronidase enzyme, GUS gene fusions may serve as a superior reporter gene system as well as an effective means of altering cellular phenotype. There are also implementations in conjunction with recombinant glucuronide permease (see below), which may be used to render host cells permeable to β-glucuronidase substrates. Issued in the United States as Patent Numbers 5,268,463, 5,432,081 and 5,599,670.
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