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A bar gene from Streptomyces viridochromogenes

photo4The patent family discussed here is assigned to Hoechst AG. The patents in this family have restricted scope: the main independent claims are limited to a bar gene isolated from one specific strain of Streptomyces viridochromogenes (Actinobacteria: Actinomycetales), best exemplified by European patent EP 257542 B1, and the same gene, codon-optimized for expression in plant cells, as in patent EP 275975 B1. These patents, which fall within the literal scope of the claims of the assigned patent family discussed previously, are also now part of the consolidated patent portfolio of Bayer Crop Science.

The Hoechst family consists of related patents and applications in many jurisdictions, including several in Europe, as well as in Australia, Canada, China, Israel, Japan, New Zealand, South Africa and the U.S. Unusually, no PCT application was filed for conversion into the numerous jurisdictions.

A summary of the claims in this patent family can be seen below.

Assigned to Hoechst AG

EP 257542 B1

2 Mar 1988

A bar gene obtained from a Streptomyces viridochromogenes strain* and plant cells transformed with that gene. Also a process to acetylate PPT using bacteria expressing the gene and the enzyme as such. 

EP 275957 B1

27 Aug 1988

A plant codon-optimized bar gene isolated from the same bacterial strain as above*. The modifications consist of an altered G/C ratio and elimination of potentially deleterious palindromic sequences. 

US 5273894

28 Dec 1993

A bar gene obtained from same bacterial strain as above* and plant cells transformed with that gene. Also a process to acetylate PPT using bacteria expressing the gene and the enzyme as such. 

US 5637489

10 Jun 1997

A process to produce plant cells resistant to PPT by introducing the same bar gene described above and the resulting resistant plants. 

US 5879903

9 Mar 1999

A method to select bacterial or plant cells using the bar gene described above as a selectable marker. 

US 5276268

4 Jan 1994

A plant codon-optimized bar gene isolated from same bacterium as above*. Modifications consist of an altered G/C ratio and elimination of potentially deleterious palindromic sequences. 

Related patents: EP in force in Germany DE 3778792 C0, Austria AT 75776, Belgium, Switzerland, France, Great Britain, Greece GR 3005200, Spain ES 2038631 T3, Italy, Sweden; other related patents: Australia AU 604743, Canada CA 1337597, CA 1321364, Finland FI 100251 B1, Hungary HU 217208 B, HU 215079 B, Japan JP 2993964 B2, JP 2749424 B2, JP 2815847 B2, JP 3093686 B2, JP 7097994 B4. Related applications: China CN 1040772 B, CN 1225393, Denmark DK 4378/87, Finland FI 88/0216, Greece GR 3007859 T3, Israel IL 83604 A0, IL 85143 A0, Japan JP 7097994 B4, JP 3103193 A2, JP 63071183 A2, JP 63273479 A2, JP 7147985 A2, JP 9107981 A2, JP 10080278 A2, JP 10080289 A2, New Zealand NZ 221526 A, South Africa ZA 87/06210 A, ZA 88/00368 A

*Streptomyces viridochromogenes strain DSM 40736 (catalog #DSM 4112, deposit under the Budapest Convention) obtained from the German Collection of Microorganisms and Cell Cultures (DSMZ).

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