Co-integrated Vectors

Overview

In general, these vectors are constructed by recombining an Agrobacterium Ti plasmid lacking tumor-causing genes ("disarmed" Ti plasmid) and a small vector plasmid, which is engineered to carry a gene of interest between a right and a left T-DNA border of the T-DNA region (engineered or modified T-DNA region). Recombination takes place through a single crossover event between a homologous region present in both plasmids.

Although co-integrated vectors have become less popular in recent years due to some difficulties encountered in engineering them, they are still used to a certain extent when modified, for example, to allow site-specific recombination of the plasmids within the Agrobacterium genome.

The granted patents and patent applications directed to methods and components for the assembling of co-integrated vectors presented under this section are divided as follows:

• Patents on basic vectors and methods. This group encompasses granted patents and patent applications directed to the basic forms of co-integrated vectors, including the primary elements of the plasmids that recombine and basic methods for their assembling.
• Patents on modified vectors and methods. This group includes granted patents and patent applications directed to improved co-integrated vectors and methods for their use.

The information contained in this page was believed to be correct at the time it was collated. New patents and patent applications, altered status of patents, and case law may have resulted in changes in the landscape. CAMBIA makes no warranty that it is correct or up to date at this time and accepts no liability for any use that might be made of it. Corrections or updates to the information are welcome. Please send an email to info@bios.net.

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